Genetics and Cancer - DNA Testing For Cancer Genetic Susceptibility Genes
There are a growing number of genes being discovered that predispose a person to developing cancer for which testing is available. Due to the complexity of the testing and the issues surrounding testing, the American Society of Clinical Oncology (ASCO) has published guidelines on when to offer cancer predisposition testing to patients. These guidelines were most recently updated in 2003.
ASCO recommends that cancer predisposition testing be offered only when:
- the individual has personal or family history features suggestive of a genetic cancer susceptibility condition
- the genetic test can be adequately interpreted
- the results will aid in the diagnosis or influence the medical or surgical management of the patient or family members with hereditary risk of cancer
ASCO further states that although the list of genes for cancer susceptibility syndromes continues to grow, the ever-changing nature of the field highlights the importance of getting genetic counseling both before and after doing genetic testing.
In general, a definitive genetic test result may have considerable medical and psychological significance. A negative test (finding no mutation) in a family with a known gene mutation may provide significant relief regarding personal cancer risk and the risk to one's children, and may help these people avoid unnecessary medical or surgical interventions. A positive test may lead to earlier or more frequent surveillance and consideration of prevention options and may influence disease management.
But genetic testing may also pose several risks. A positive genetic test and subsequent interventions may cause the patient or family distress. A negative test (not finding a known mutation in the gene analyzed) may result in undue reassurance for a person who may still be at markedly increased cancer risk based on their family history. Furthermore, some test results may be unclear, which may be frustrating or lead people to the wrong conclusions. It is very important that people have a good understanding of what the tests may or may not tell them before they have them done.
Because of the medical, social, and legal ramifications associated with genetic test results, ASCO strongly recommends that genetic testing be done only when paired with pre- and post-test counseling. This ensures that patients are aware of the potential implications of their test results in the context of their decision of whether to seek testing. Full discussion after testing will also ensure that patients make informed medical decisions on receipt of test results.
Click here to view the
Online Resources of Cancer Center
Disclaimer - This content is reviewed periodically and is subject to change as new health information becomes available. The information provided is intended to be informative and educational and is not a replacement for professional evaluation, advice, diagnosis or treatment by a healthcare professional. © 2009 Staywell Custom Communications.